Evaluation of in situ setting calcium phosphate cements as carrier materials for antibiotics

摘要

The release of gentamicin from CPC and FCPC both increased with increasing initial drug content. Even though the indentation load decreased in presence of gentamicin sulfate, the cements impregnated with the antibiotic could still set ～ 10 minutes under physiological conditions. The compressive strength of cured CPC and FCPC was not statistically affected by the various amounts of gentamicin added in the cements. Altogether, the two calcium phosphate cements evaluated in this study showed their potentials as carriers for controlled local delivery of antibiotics.