Clot lysis on lysine-coated peripheral stents preadsorbed with tPA

摘要

Thrombosis often occurs when an implanted medical device comes in contact with blood and frequently results in device failure. Anti-thrombotic strategies typically attempt to limit the deposition of coagulation proteins and the cellular components of blood, thus inhibiting thrombus growth. Our focus has been the development of a coating reagent containing pendant lysine groups mat can be easily applied as a thin-film and covalently attached to a surface. We have shown previously that this reagent preferentially binds plasminogen and tissue-type plasminogen activator (tPA) from plasma, thereby promoting clot lysis. In the work reported here, the lysine-coating reagent has been applied to a peripheral vascular stent and data on blood interactions of the coated stent have been developed.