Capillary Flow Networks in Collagen-Based Scaffolds for Microvascularized Tissue-Engineered Products

摘要

Byrnengineering a built-in microvasculature in vitro before implantation, TE products can overcome mass transfer limitations. To this effect, we have developed a new techniquernto transfer rationally designed flow networks onto a natural biopolymeric collagen-GAG scaffold. This technique is amenable for adaptation in other scaffold materials, and can be used for making TE skin with built-in flow channels. Further, we have demonstrated endothelial cell attachment and viability in our scaffolds.