In-Vitro biological response of calcium phosphate ceramics synthesized by using recycled eggshell

摘要

In orthopedic, maxillofacial surgery and dental areas, freshly harvested autologous cancellous bone is regarded as a golden standard for a bone grafting due to the good and fast osseous integration. However, the autografting of the bone is limited due to the donor site morbidity and limited availability. It is generally acknowledged that calcium phosphate ceramics like hydroxyapatite (HA) and tricalcium phosphate (TCP) are a good candidate for bone substitutes due to their chemical similarity to bone mineral. Additionally, bone substitutes should have degradation characteristics that allow the organism to replace the foreign material by fully functional bone in a balanced time schedule.rnIn mis work, the HA and β-TCP powders were synthesized by a new wet-chemical method using eggshell and phosphoric acid. The biocompatibility of synthesized natural HA, HA/β-TCP (50:50) and β-TCP derived from eggshell was compared with those of as commercial chemical powder with hBMSCs.