Bone Matrix and Deminerallzed Bone Matrix Incorporated PLGA Matrices for Long-term Bone Repair and Bone Tissue Engineering

摘要

Using PLGA as a carrier for both BM and DBM powder provides controlled release of OI factors. Therefore, BM/PLGA and DBM/PLGA can be used at target sites to release OI factors avoiding particle migration and immediate dispersion with blood serum. Since the PLGA matrix is completely degradable, it could be implanted close to the site where it is needed, such as in the bone to treat bone fracture. This type of matrices can be potentially used for bone tissue engineering applications where BMSCs seeded and cultured in-vitro onto polymer scaffolds prior to implantation at target site. Since synthetic polymer scaffolds are biologically inert, BM or DBM powder can be incorporated into polymer scaffolds in order to achieve OC and OI properties.