Applications of nonlinear laser nano/microlithography: fabrication from nanophotonic to biomedical components

摘要

In this work we present the latest results in the application of multi-photon polymerization for tissue engineering, by fabricating microstructured artificial 3D scaffolds for stem cell growth. Microstructuring of large scale 3D scaffolds is investigated arid the direct laser writing technique is supplemented by fabrication by multi-beam interference and micromolding of large scale structures. Within the limitation of our study, we conclude that the proposed nonlinear direct laser writing technique offers rapid and flexible fabrication of biomedical components with required shape, pore size and general porosity. The applications could target biostable and biodegradable implants applied for bone or tissue replacement as well as drug delivery or release agents.