Particle Design for Recent Dosage Form Development

摘要

Colloidal drug carriers, such as liposomes, lipid emulsions, and polymeric nanoparticles have great potential to provide effective drug delivery. A variety of investigations have been carried out for designing an optimal paniculate system for drug delivery in topical administration as well as in systemic administration. Liposome is one of most promising drug carriers, because its particle size and surface charge are easily controlled. We have also demonstrated feasibility of surface design of liposomes by coating its surface with functional polymers. The resultant polymer-coated liposomes showed higher stability in storage, prolonged blood circulation after intravenous injection, and mucoadhesive property. This presentation mainly demonstrates recent successful results with liposomal drug delivery systems in oral, pulmonary and ocular administration after showing the basic concept of polymer-coating liposomes and their behavior after administration. Recent trends in developing dosage forms will be also mentioned in the point of particle design.