EFFECTIVE HYPOTHERMIC STORAGE OF HUMAN PLURIPOTENT STEM CELL-DERIVED CARDIOMYOCYTES COMPATIBLE WITH GLOBAL DISTRIBUTION OF CELLS FOR CLINICAL APPLICATIONS AND TOXICOLOGY TESTING

摘要

The applicability of human pluripotent stem cell-derived cardiomyocytes (hPSC-CMs) in the clinic/industry is highly dependent on the development of efficient methods for worldwide shipment of these cells. Here, we evaluated the feasibility to cold store monolayers and aggregates of functional CMs obtained from different PSC lines using a fully defined clinical-compatible preservation formulation and investigated the time frame that hPSC-CMs could be subjected to hypothermic storage.