Implementation of near-infrared spectroscopy in a rat model of cardiac arrest and resuscitation

摘要

Transient global cerebral ischemia accompanying cardiac arrest (CA) often leads to permanent brain damage with poor neurological outcome. The precise chain of events underlying the cerebral damage after CA is still not fully understood. Progress in this area may profit from the development of new non-invasive tools that provide real-time information on the vascular and cellular processes preceding the damage. One way to assess these processes is through near-infrared spectroscopy, which has demonstrated the ability to quantify changes in blood volume, hemoglobin oxygenation, cytochrome oxidase redox state, and tissue water content. Here we report on the successful implementation of this form of spectroscopy in a rat model of asphyxial CA and resuscitation, under hypothermic (34.0℃) and normothermic (37.5℃) conditions. Preliminary results are shown that provide a new temporal insight into the cerebral circulation during CA and post-resuscitation.