Cellular Self-defense Mechanisms: Modeling of the DSBs Generation and Repair Process under Ion Radiation

摘要

In response to acute perturbations from outside, cell can trigger its self-defense mechanisms to fight against genome stresses. To simulate the kinetics of cellular to respond to DNA damage at single cell level, a model of the double strand breaks (DSBs) generation and repair process was proposed under continuous IR. The model can be successfully used to present the kinetics of DSBs generation and their repair, as well as the complicated interactions among vital components during the continuous radiation time. In different IR dose domains, the simulations suggest that the capability of cellular responding to DNA damage begin to decrease as IR overpasses some strength threshold.