KNOWLEDGE-DRIVEN ANALYSIS AND DATA INTEGRATION FOR HIGH-THROUGHPUT BIOLOGICAL DATA

摘要

There is a data explosion overtaking medicine and biology due to the development of high-throughput technologies for measuring most molecular constituents of cells. Novel sequencing approaches are now nearing the $1000 genome. SNPchips already measure individual genetic variation for the same cost, and microrarrays provide a global picture of the transcripts, with miRNAs and exon level analyses beginning. Proteomic measurements, both from mass spectrometry and from antibody arrays, are probing increasing amounts of the proteome, and NMR techniques are doing the same for metabolic components. The goal is a deeper view into the complexity of biological systems, with the ultimate prize being personalized medicine and finely targeted therapies.