Boron Neutron Capture Therapy-Recent Aspect, a change from Thermal Neutron to Eptithermal Neutron Beam and a new protocol

摘要

SInce 1968, One-hundred seventy three patients with glioblastoma, anaplastic astrocytoma , low grade astrocytoma or other types of tumor were treated by boron-neutron capture therapy using a combination of thermal neutron and BSH is 5 reactors. Out of 101 patients with glioma treated by BNCT under the recent protocol, 33 patients lived or have lived longer than 3 years. Nine of these 33 lived or have lived longer than 10 years. According to the retrospective analysis, the important factors related to e clinical results were tumor dose radiation dose and maximum radiation dose in the normal brain cortex. The result was not satisfied as it was expected. Then, we decided to introduce mixed beams which contain thermal neutron and epithermal neutron beams. KUR was reconstructed in 1996 and developed to be availlable to use mixed beams. Following the shutdown of the JRR-2, JRR-4 was reneweed for medical use in 1998. BOth reactors ahve capacity to yield thermal neutron beam, epithermal neutron beam and mixed beams. The development of the neutron source lead us to make a new protocol.