A Rechargeable Antibacterial Poly (ethylene-co-methacrylic acid) (PE-co-MAA) Nanofibrous Membrane: Fabrication and Evaluation

摘要

@@ Nano-fibrous membranes have attracted much attention for various unique applications including sensors,filtration media,biomedical materials and protective clothing.1"4 Their extraordinary high surface area to volume ratios and open porous structures also make the membranes an excellent candidate for antibacterial materials since they provide maximum surface contact to bacteria cells. A number of antimicrobial agents can be incorporated to the nanofibers matrix,i.e. heavy metals,quaternary ammonium compounds or antibiotics5'8. Among these biocides,N-halamine structures have features of high efficiency,durability and rechargeability to kill bacteria,making them ideal functions for air and water filtering materials. Some antibacterial nanofibrous membranes with N-halamine precursors have been developed by using electrospinning method.11,12 In these cases,N-halamine moieties were physically incorporated into the nanofibrous membrane through simple mixing two or more components in electrospinning solutions. However,the embedded agents could be released and become completely exhausted during usage,affecting durability and rechargeability of the products. An alternative strategy is to covalently incorporate N-halamine precursors onto the surface of nanofibers,which may introduce antimicrobial function permanently.