Enhancement of Oral Absorption of Curcumin by Microparticle Drug Delivery Systems

摘要

@@Curcumin, a yellow polyphenol derived from the rhizome of turmetic has a wide spectrum of biological and pharmacological activities [1]. But the actual use of curcumin in clinic is still limited because of its poor solubility, stability, and bioavailability [2]. In this paper curcumin-loaded chitosan microparticles were prepared for the stabilization of curcumin and its controlled delivery. And the solubility, stability and bioavailability of curcumin incorporated in the microparticles have also been evaluated. Microparticles were prepared by the ionic gelation technique [3]. Chitosan solution 10mg/ml and curcumin solution 10mg/ml were mixed by mechanical stirring. The ratio of curcumin chitosan was 1:1. The particles were formed spontaneously upon addition of an aqueous TPP solution (0.3%, W/V) to the mixed solution under magnetic stirring with the infusing rate at 1drop/3s, mixing speed at 1000r/min, and mixing duration of 10min.