Efficient Catalytic Asymmetric Synthesis of α-Substituted Phenyloxyacetyloxy and Aroyloxy Phosphonates

摘要

Optically active α-substituted phenoxyacetyloxy and aroyloxy phosphonates have been synthesized via catalytic asymmetric hydrogenation of the corresponding prochiral α, β- unsaturated phosphonates using Rh (I)/(R, R)-Me-DuPhos as the catalyst in methanol at 18℃. The asymmetric hydrogenation reaction exhibits excellent enantioselectivity with enantiomeric excesses from 91% to 96%.