Affinity membrane having high specificity and seklection used for purifying bioprod-ucts from omplex and dilute mixture has been quickly developed during last ten years~(1-3). A functional group named ligand is covalently bound to chemically modified membrane surface (both outer and inner surface in the pores). When a mixture feed solution containing mamed ligate modlecules to be seapratedf lows through the affinity membrane, the target compound (ligate) wil lbe specifically and reversiblely adsorbed on it to form a complex. In order to cleave the complex from the membrane, a salt solution containing a compound with greater than target moklecule affinity with ligand passes through the membrane under pressure driving by pump, so that principle we have prepared several affinity membranes for use in bioproduct separations and purifications such as trypsin inhibitor~(4), alkaline phos-phatase~(5), human serum albumin and alpha-interferon~(6,7).
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