首页> 外文会议>Physiology, Function, and Structure from Medical Images pt.2; Progress in Biomedical Optics and Imaging; vol.6, no.23 >Improved sensitivity of dynamic CT with a new visualization method for radial distribution of lung nodule enhancement
【24h】

Improved sensitivity of dynamic CT with a new visualization method for radial distribution of lung nodule enhancement

机译:利用新的可视化方法增强肺结节放射状分布的动态可视化方法提高了动态CT的敏感性

获取原文
获取原文并翻译 | 示例

摘要

For differential diagnosis of pulmonary nodules, assessment of contrast enhancement at chest CT scans after administration of contrast agent has been suggested. Likelihood of malignancy is considered very low if the contrast enhancement is lower than a certain threshold (10-20 HU). Automated average density measurement methods have been developed for that purpose. However, a certain fraction of malignant nodules does not exhibit significant enhancement when averaged over the whole nodule volume. The purpose of this paper is to test a new method for reduction of false negative results. We have investigated a method of showing not only a single averaged contrast enhancement number, but a more detailed enhancement curve for each nodule, showing the enhancement as a function of distance to boundary. A test set consisting of 11 malignant and 11 benign pulmonary lesions was used for validation, with diagnoses known from biopsy or follow-up for more than 24 months. For each nodule dynamic CT scans were available: the unenhanced native scan and scans after 60, 120, 180 and 240 seconds after onset of contrast injection (1-4 mm reconstructed slice thickness). The suggested method for measurement and visualization of contrast enhancement as radially resolved curves has reduced false negative results (apparently unenhancing but truly malignant nodules), and thus improved sensitivity. It proved to be a valuable tool for differential diagnosis between malignant and benign lesions using dynamic CT.
机译:为了鉴别诊断肺结节,已建议在给予造影剂后在胸部CT扫描中评估造影剂的增强作用。如果对比度增强低于某个阈值(10-20 HU),则恶性可能性很低。为此,已经开发了自动平均密度测量方法。但是,当平均整个结节体积时,一定比例的恶性结节不会表现出明显的增强。本文的目的是测试一种减少假阴性结果的新方法。我们研究了一种不仅显示单个平均对比度增强数,而且还显示每个结节更详细的增强曲线的方法,该曲线显示了增强与边界距离的关系。由11个恶性和11个良性肺部病变组成的测试集用于验证,活检或随访已知的诊断超过24个月。对于每个结节,都可以使用动态CT扫描:未增强的自然扫描以及在造影剂注射开始后60、120、180和240秒(1-4毫米重建的切片厚度)后进行的扫描。建议的用于测量和可视化对比度增强(作为径向分辨的曲线)的方法减少了假阴性结果(显然没有增强,但实际上是恶性结节),因此提高了灵敏度。它被证明是利用动态CT鉴别恶性和良性病变的有价值的工具。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱:kefu@zhangqiaokeyan.com

京公网安备:11010802029741号 ICP备案号:京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有
  • 客服微信

  • 服务号