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Elemental Spectrum of a Mouse Obtained via Neutron Stimulation

机译:通过中子刺激获得的小鼠的元素光谱

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Several studies have shown that the concentration of certain elements may be a disease indicator. We are developing a spectroscopic imaging technique, Neutron Stimulated Emission Computed Tomography (NSECT), to non-invasively measure and image elemental concentrations within the body. The region of interest is interrogated via a beam of high-energy neutrons that excite elemental nuclei through inelastic scatter. These excited nuclei then relax by emitting characteristic gamma radiation. Acquiring the gamma energy spectrum in a tomographic geometry allows reconstruction of elemental concentration images. Our previous studies have demonstrated NSECT's ability to obtain spectra and images of known elements and phantoms, as well as, initial interrogations of biological tissue. Here, we describe the results obtained from NSECT interrogation of a fixed mouse specimen. The specimen was interrogated via a 5MeV neutron beam for 9.3 hours in order to ensure reasonable counting statistics. The gamma energy spectrum was obtained using two High-Purity Germanium (HPGe) clover detectors. A background spectrum was obtained by interrogating a specimen container containing 50mL of 0.9% NaCl solution. Several elements of biological interest including ~(12)C, ~(40)Ca,~(31)P, and ~(39)K were identified with greater then 90% confidence. This interrogation demonstrates the feasibility of NSECT interrogation of small animals. Interrogation with a commercial neutron source that provides higher neutron flux and lower energy (~2.5MeV) neutrons would reduce scanning time and eliminate background from certain elements.
机译:多项研究表明,某些元素的浓度可能是疾病的指标。我们正在开发一种光谱成像技术,即中子激发发射计算机断层扫描(NSECT),以无创方式测量和成像体内的元素浓度。感兴趣的区域通过高能中子束进行询问,该束中子通过非弹性散射激发元素核。然后,这些激发的核通过发射特征性的伽玛射线而松弛。在断层摄影几何中获取伽马能谱可以重建元素浓度图像。我们以前的研究证明了NSECT能够获取已知元素和体模的光谱和图像,以及对生物组织的初步询问。在这里,我们描述了从固定小鼠标本的NSECT询问中获得的结果。为了确保合理的计数统计,通过5MeV中子束对样本进行了9.3小时的询问。伽马能谱是使用两个高纯锗(HPGe)三叶草检测器获得的。通过询问包含50mL的0.9%NaCl溶液的标本容器获得背景光谱。确定了一些具有生物学意义的元素,包括〜(12)C,〜(40)Ca,〜(31)P和〜(39)K,置信度大于90%。这种审讯证明了对小动物进行NSECT审讯的可行性。用提供更高中子通量和较低能量(〜2.5MeV)的中子的商业中子源进行询问将减少扫描时间并消除某些元素的背景。

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