Non-invasive Detection of Glucose Concentration by Differential Absorption OCI with Two Wavelengths

摘要

We present a new method of glucose concentration detection with a differential absorption optical low-coherent interferometry (DAOCI) technique. In our system, we uses two OCI signals recorded by turns in one period with the same detector. Two different light sources are selected corresponding to the different absorption coefficient of the glucose absorption band. The ratio of the two intensities depends on the concentration of the glucose in samples. With the known difference in the absorption cross section or experimental data, it is possible to calculate the mean glucose concentration of samples. In our experiment, we measured a series of glucose solution in a cuvette, and the systemic resolution we got is 16.14mg/dL which achieves the required accuracy(20mg/dL) for practical application. The results prove the feasibility of this method to be used for no-invasive detection of glucose in the aqueous humor.