Noninvasive measurement of glucose concentration using OCT based on the extended Huygens-Fresnel principle

摘要

We have developed a noninvasive method to monitor the glucose concentration in tissue phantom used the OCT model which based on the extended Huygens-Fresnel (EHF) principle. The changes of the optical properties such as the rnscattering coefficient μ_s, the anisotropy factor g and the effective scattering coefficient μ_s with the increase of the rnglucose concentration in 10% Intralipid solution were obtained. The results showed that the scattering coefficient μ_s decreased when the glucose concentration increased in the solution, which is accorded with the conclusions by others. Contrarily, the factor g increased when the glucose concentration grown up. As a result, the coefficient μ_s is fall with the increased of the glucose concentration. Comparing with those previously reported in which only got the relative value of scattering coefficient μ_s, the most important advantage of our model is that we got the practical value of μ_s, grnand μ_s. All of these reveal that the OCT EHF model is a promising method which is adapted to detect the glucose concentration in solution, and it will be applied in medical fields someday.