Mechanisms of interaction between very high-frequency photoacoustic waves and the skin

摘要

The aim of this work is to improve the understanding of the interaction between photoacoustic waves and skin. We employ photoacoustic waves with 1 MPa amplitude and center frequencies of 100 MHz to transiently perturb model lipid membranes and the stratum corneum of mini pigs. The lipid structure transient perturbation observed is tentatively attributed to a temperature rise mechanism. We also try to show that the dynamic acoustic radiation force mechanism can explain the perturbation induced by photoacoustic waves in skin. Indeed, 15 bar pressure gradients across 5 corneocytes (approx. 5 μm wide) are shown to transiently perturb the skin structure.