Controlling optical properties of bio-tissue by the use of biocompatible hyperosmotic agents

摘要

Previous results of tissue optical clearing have qualitatively indicated that optical properties of bio-tissue can be changed by the use of biocompatible hyperosmotic agents. In this talk, it is our aim to try to quantitatively evaluate how relative between changes of optical properties and hyperosmotic agents. Tissue-like turbid media, i.e. intralipid-10% suspension and porcine skin tissues, medicated without and with biocompatible hyperosmotic agents, have been investigated within NIR range. Optical parameters (absorption coefficient, scattering coefficient and anisotropy factor) of samples have been calculated by Inverse Adding-Doubling (IAD) modelling method. The results have demonstrated that optical property parameters (absorption coefficient, scattering coefficient and anisotropy factor) of tissue samples have changed with the course of the administration of biocompatible hyperosmotic agents into intralipid-10% suspension and porcine skin tissues respectively. This reveals better refractive index matching environment has been gradually created within tissue. Further, the results have showed the potential capabilities to quantitatively control optical properties of bio-tissue in this way. Therefore, this would facilitate explanation of the mechanism of tissue optical clearing by the use of biocompatible hyperosmotic agents.