Photodynamic therapy in the prophylactic management of bladder cancer

摘要

Abstract: Nine patients were treated with red light whole bladder photodynamic therapy (WBPDT): five had mucosal involvement (T$-a$/) and four submucosal invasion (T$-1$/). Patients received slow intravenous injection with 2mg/kg body weight of photofrin 48-72 hours before undergoing global light treatment via a 22-French cystoscope with a 400-micron quartz fiber bulb (isotropic) tip fiber. Three months after PDT, eight of the patients had normal cystoscopy, and negative biopsy and urine cytology. Two patients who had recurrences at six and twelve months were retreated with a higher dose (20 J/cm$+2$/). They had no increased morbidity and no evidence of recurrent disease six months later. WBPDT should be considered as an important alternative treatment for patients who have recurrent or refractory superficial bladder cancer.!