Overview of computational simulations for PDT treatments based on optimal choice of singlet oxygen

摘要

Effective photodynamic therapy (PDT) treatment planning and treatment monitoring requires computer simulations of both light transport in tissue and photosensitizer (PS) photophysics to accurately estimate singlet oxygen. Simply using fixed prescribed values of light dose (fiuence) or PDT dose (the time integral of 'PS concentration' times the 'fluence rate') - one value for all patients - does not account for differences in the amount of singlet oxygen formed when fluence rates change or patient tissue parameters change. We will focus on singlet oxygen dose which is calculated by solving the photokinetics rate equations and which determines the effectiveness of the subsequent reactions of singlet oxygen with the cancer target and the negative effect of PS photobleaching.