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Broadband Fourier domain mode-locked laser for optical coherence tomography at 1060 nm

机译:宽带傅里叶域锁模激光器用于1060 nm的光学相干断层扫描

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摘要

Optical coherence tomography (OCT) in the 1060 nm range is interesting for in vivo imaging of the human posterior eye segment (retina, choroid, sclera) due to low absorption in water and deep penetration into the tissue. Rapidly tunable light sources, such as Fourier domain mode-locked (FDML) lasers, enable acquisition of densely sampled three-dimensional datasets covering a wide field of view. However, semiconductor optical amplifiers (SOAs)—the typical laser gain media for swept sources—for the 1060 nm band could until recently only provide relatively low output power and bandwidth. We have implemented an FDML laser using a new SOA featuring broad gain bandwidth and high output power. The output spectrum coincides with the wavelength range of minimal water absorption, making the light source ideal for OCT imaging of the posterior eye segment. With a moderate SOA current (270 mA) we achieve up to 100 nm total sweep range and 12 μm depth resolution in air. By modulating the current, we can optimize the output spectrum and thereby improve the resolution to 9pm in air (~6.5um in tissue). The average output power is higher than 20mW. Both sweep directions show similar performance; hence, both can be used for OCT imaging. This enables an A-scan rate of 350 kHz without buffering the light source output.
机译:由于在水中的低吸收和对组织的深层渗透,因此1060 nm范围的光学相干断层扫描(OCT)对于人后眼节(视网膜,脉络膜,巩膜)的体内成像非常有趣。诸如傅立叶域锁模(FDML)激光器之类的快速可调光源可以采集覆盖广泛视域的密集采样的三维数据集。但是,直到1060 nm波段的半导体光放大器(SOA)(用于扫频光源的典型激光增益介质)直到最近才只能提供相对较低的输出功率和带宽。我们已经使用具有宽增益带宽和高输出功率的新型SOA实现了FDML激光器。输出光谱与最小吸水率的波长范围相吻合,使该光源非常适合后眼节的OCT成像。使用适中的SOA电流(270 mA),我们在空气中的扫描范围可达100 nm,深度分辨率为12μm。通过调制电流,我们可以优化输出频谱,从而将分辨率提高到空气中的9pm(组织中约为6.5um)。平均输出功率高于20mW。两种扫描方向均显示相似的性能;因此,两者均可用于OCT成像。这样就可以在不缓冲光源输出的情况下实现350 kHz的A扫描速率。

著录项

  • 来源
  • 会议地点 San Francisco CA(US)
  • 作者单位

    DTU Fotonik, Department of Photonics Engineering, Technical University of Denmark, P.O. Box 49, 4000 Roskilde, Denmark;

    Lehrstuhl fur BioMolekulare Optik, Ludwig-Maximilians-Universitat Miinchen, Oettingenstr. 67, 80538 Miinchen, Germany;

    Lehrstuhl fur BioMolekulare Optik, Ludwig-Maximilians-Universitat Miinchen, Oettingenstr. 67, 80538 Miinchen, Germany;

    Center for Medical Physics and Biomedical Engineering, Medical University of Vienna, Wahringer Giirtel 18-20, 4L, 1090 Wien, Austria;

    Center for Medical Physics and Biomedical Engineering, Medical University of Vienna, Wahringer Giirtel 18-20, 4L, 1090 Wien, Austria;

    Lehrstuhl fur BioMolekulare Optik, Ludwig-Maximilians-Universitat Miinchen, Oettingenstr. 67, 80538 Miinchen, Germany;

    DTU Fotonik, Department of Photonics Engineering, Technical University of Denmark, P.O. Box 49, 4000 Roskilde, Denmark;

    Center for Medical Physics and Biomedical Engineering, Medical University of Vienna, Wahringer Giirtel 18-20, 4L, 1090 Wien, Austria;

    Lehrstuhl fur BioMolekulare Optik, Ludwig-Maximilians-Universitat Miinchen, Oettingenstr. 67, 80538 Miinchen, Germany;

    DTU Fotonik, Department of Photonics Engineering, Technical University of Denmark, P.O. Box 49, 4000 Roskilde, Denmark;

  • 会议组织
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 生物医学工程;
  • 关键词

  • 入库时间 2022-08-26 13:44:37

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