Depth-resolved tumor phantom detection by second-generation photosensitizers

摘要

Abstract: Determination of the tumor's penetration into the tissue is actual task of optical biopsy. For this aim the depth resolved fluorescence of the second generation sensitizer's molecules has been studied in tissue's phantom at different excitation wavelength. Fluorescence spectra from the superficially and deeply (up to 10 mm) located Chlorin e$-6$/ sensitizer's molecules at 355, 532, 660 nm laser excitation were registered. The comparison of the fluorescence signals registered at the different values of penetration into tissues of the probing radiation gives opportunity to define the presence of the sensitizer's molecules in different depth of tissue and to reveal such important clinical parameter as tumor's penetration into depth. !6