Phosphorylcholine-protected Nanoparticles Functionalized with Both Magnetic and Photoluminescent Properties

摘要

With an aim to prepare biomedical nanoparticles with core-shell morphologies displaying both magnetic and photoluminescent properties, a zinc sulfide thin layer coated on an iron oxide nanoparticle surface was utilized and protected by a biocompatible surfactant, 11-mercaptoundecylphosporylcholine (SPC), to stably disperse in biology systems. TEM image confirmed the ferric oxide core and ZnS shell morphologies of nanoparticle with 9 nm of diameter. An emission ZnS band centered at 425 nm (excited at 330 nm) was found from the photoluminescence spectrum of the nanoparticles. The nanoparticles mixed with albumin in aqueous buffer solution were analyzed using HPLC separation and TEM observation, illustrating a weak interaction between proteins and nanoparticles. The culture of nanioparticles with 3T3 fibroblast cells based on various culturing periods and temperatures showed the particles internalized quickly by cells from observation by confocal microscope.