NEW CYCLIZATION AND CYCLOADDITION REACTIONS IN ORGANIC SYNTHESIS

摘要

An account of our recent studies on the rhodium-catalyzed carbo-cyclizations, cycloadditions and cyclohydrocarbonylations is presented. Silicon-initiated cascade carbocyclizations, including carbonylative carbocyclizations, provide powerful methods for the rapid construction of heterocyclic as well as carbocyclic compounds in one step. Efficient [2 + 2 + 2 + 1] cycloaddition process also furnishes an easy access to fused tricyclic systems. Cyclohydrocarbonylation reactions provide useful and efficient methods for the synthesis of a variety of nitrogen-heterocycles of medicinal interests.