Regulation of Energy Metabolism in Hepatocytes

摘要

Control analysis has been applied experimentally to many pathways (Fell, 1992). However, the effort required to measure the elasticity, control and response coefficients makes a full empirical analysis unrealistic in all but rather simple systems. Consequently, most investigations have considered single enzymes or pathways, ignoring interactions with other cellular pathways. The most experimentally accessible way to measure regulation in complex systems like whole cells is to group reactions together into much larger blocks.