Interesting applications on a novel high pressure high temperature microfluidic-based flow reactor

摘要

Recently, a novel high-pressure, high-temperature, microfluidic-based benchtop reactor was developed by ThalesNano Inc. as a result of the need for performing hazardous organic chemical reactions under harsh conditions in a safe and fast manner. Wide variety of organic chemical reactions including alkylation, esterification, nitration, hydrosylilation, bromination, different C-C-, C-N cross coupling reactions have been successfully performed on the instrument and presented here. As difficult to perform reactions, isonitrile synthesis as well as azide formation have been targeted, tested and resulted in a complete conversion of the reagents. The instrument was designed with an external gas introduction possibility to run triphasic reactions using reactive and sometime hazardous gases/mixtures like carbon monoxide used in carbonylation. Furthermore, as interesting application nanoparticle synthesis was also targeted and the first results are demonstrated here as well.