Biodistribution and Toxicity of Nanomaterials In Vivo: Effects of Composition, Size, Surface Functionalization and Route of Exposure

摘要

Rapid, relevant and efficient testing strategies are necessary to evaluate nanoparticle-biological interactions of emerging nanoparticlesanomaterials due to the anticipated, unprecedented growth of the nanotechnology industry. Here we present an approach that utilizes a dynamic whole animal (embryonic zebrafish) assay to identify in vivo responses to nanomaterial exposure and to define physicochemical properties that result in adverse biological consequences. Our results demonstrate the utility of this model as an effective and accurate tool to assess the biological activity and toxic potential of nanomaterials in a short period of time with minimal cost.