Comparison of Dermal Exposure across a Diverse Range of Consumer Products Based on Modelling Approaches Commonly Applied to Human Health Risk Assessments under Canada's Chemicals Management Plan

摘要

Canada's Chemicals Management Plan (CMP) is an initiative aimed at reducing the risk posed by chemicals to Canadians and their environment. Since 2006, more than 3000 substances have been assessed in over 260 assessment reports and this work continues in the final phase of the CMP, including integration of novel and emerging approaches where appropriate. Many of the quantitative exposure assessments to date have included products available to consumers, including personal care, household cleaning, do-it-yourself (DIY) and paint products, with exposure characterization derived using modelling tools such as ConsExpo (e.g., for cleaning products, DIY and paint products) and in-house guidance (e.g., personal care products). This poster will present findings from an analysis where dermal exposures were compared and ranked for over 100 consumer products (including mixing/loading, application and post-application activities, as appropriate). The poster will include separate exposure estimates for specific age groups (toddlers, children, teenagers and adults) thus incorporating age-specific differences in amount applied, frequency of applications, and body weight. The results of this analysis can help to prioritize key sources of consumer exposures as well as identify subpopulation of interest over a wide range of uses. This poster will also provide a relative comparison of dermal exposure associated with products as diverse as cleaning products, DIY and personal care products and, where appropriate, may facilitate clustering or grouping of products with similar dermal exposure potential.