Magnesium ions facilitate integrin alpha-2 and alpha-3-mediated proliferation and partially promotes differentiation in hBMSCs

摘要

Discussion and This findings indicate that the proliferation of hBMSCs is mediated by integrin alpha-2 and alpha-3 expression and the differentiation of hBMSCs is at least in part improved by enhanced ALP activity and expression exposed by magnesium ions. Collectively, exposure to magnesium facilitated proliferation rates via alpha-2 and alpha-3 expression, and partially promoted differentiation into osteoblast via the alteration of ALP expression and activity. Accordingly, magnesium can be utilized as a useful biomaterial for orthopedics.