Osseointegration Effect of BMP-2 on Dental Implants: A 3-6 Week In Vivo Study

摘要

Earlier studies have demonstrated the superiority of calcium phosphate as a material component in dental and bone implants when compared to titanium. Thus, the significant difference in osseointegration between the two surface types is not an unexpected result. As an implant surface, plasma-spray treated calcium phosphate exhibited a higher degree of bone-implant contact over that of titanium with more than a 50% increase in the presence of rhBMP-2 at 3 weeks relative to its uncoated counterpart. Our results suggest that the PSCaP implant surface is more amenable to adsorption of bone morphogenic protein for early healing release. For future studies, earlier time points must be considered in order to further investigate the effect of rhBMP-2 on osseointegration in terms of measurable parameters and kinetics.