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Expression of Sonic Hedgehog in Non-Diabetic Wounds Treated with Poly(Methacrylic Acid-co-Methyl Methacrylate)

机译:用聚(甲基丙烯酸 - 甲基丙烯酸甲基丙烯酸甲基丙烯酸甲基丙烯酸甲基丙烯酸甲基丙烯酸甲基丙烯酸甲基丙烯酸甲基丙烯酸甲基丙烯酸甲酯)表达Sonic Hedgehog在非糖尿病伤口中的表达

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摘要

In the wound healing study, in non-diabetic animals, MAA treatment increased vessel density and expression of Shh, Ptchl, Gli2 and Gli3 in the wound tissue, and Shh+ cell density in the tissue surrounding the wound bed suggesting activation of the Shh signaling pathway and its involvement in MAA-mediated angiogenesis. Subcutaneous injection studies are on-going to further characterize the in vivo source of Shh.
机译:在伤口愈合研究中,在非糖尿病动物中,MAA治疗增加了血管密度和SHH,PTCH1,GLI2和GLI3的表达在伤口组织中,以及围绕伤口床的组织中的SHH +细胞密度提出了SHH信号通路的激活及其参与Maa介导的血管生成。皮下注射研究正在进行进一步表征体内SHH的体内源。

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