The panel of assays we designed provided a comprehensive assessment on decellularized ECM scaffolds effects on cells. The innate biological properties of biomaterials are not only defined by their original sources, but also include manufacturer processing techniques. Surface composition as well as pore size and thickness are major factors influencing cell infiltration and migration in the early stage of wound healing. Among tested ECM materials, Meso Biomatrix and Oasis have unique characteristics that facilitate scaffold incorporation, making them promising choices for a variety of clinical applications. Additional investigation into the long-term response of host tissue to biological materials will help develop guiding principles for biomaterial design.
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