Biological evaluation of neoaspergillic acid, a pyrazine hydroxamic acid produced by mixed cultures of two marine-derived mangrove epiphytic fungi

摘要

Neoaspergillic acid (NAA), a pyrazine hydroxamic acid, was produced by mixed cultures of two epiphytic fungi from a rotten fruit of mangrove Avicennia marina from the South China Sea. In the in vitro bioassays, NAA shows significant inhibitory activities against some Gram-positive and Gram-negative bacteria with MIC ranges of 0.49 – 15.62 µg/mL, and also exhibits moderate inhibitory activities against human cancer cell lines SPC-A-1, BEL-7402, SGC-7901 and K562 with IC50 ranges of 7.99 – 24.90 µg/mL.