Deep Learning in Computer-Aided Diagnosis Incorporating Mammographic Characteristics of both Tumor and Parenchyma Stroma

摘要

We investigated the additive role of breast parenchyma stroma in the computer-aided diagnosis (CADx) of tumors on full-field digital mammograms (FFDM) by combining images of the tumor and contralateral normal parenchyma information via deep learning. The study included 182 breast lesions in which 106 were malignant and 76 were benign. All FFDM images were acquired using a GE 2000D Senographe system and retrospectively collected under an Institution Review Board (IRB) approved, Health Insurance Portability and Accountability Act (HIPAA) compliant protocol. Convolutional neutral networks (CNNs) with transfer learning were used to extract image-based characteristics of lesions and of parenchymal patterns (on the contralateral breast) directly from the FFDM images. Classification performance was evaluated and compared between analysis of only tumors and that of combined tumor and parenchymal patterns in the task of distinguishing between malignant and benign cases with the area under the Receiver Operating Characteristic (ROC) curve (AUC) used as the figure of merit. Using only lesion image data, the transfer learning method yielded an AUC value of 0.871 (SE=0.025) and using combined information from both lesion and parenchyma analyses, an AUC value of 0.911 (SE=0.021) was observed. This improvement was statistically significant (p-value=0.0362). Thus, we conclude that using CNNs with transfer learning to combine extracted image information of both tumor and parenchyma may improve breast cancer diagnosis.