Co-occurrence of Core of Binding Sites for Transcription Factors in Intronic Region of Saccharomyces Cerevisiae Ribosomal Protein Genes

摘要

Eukaryotic transcriptional regulation is complex. Typically, it takes place by cooperative regulation. A number of studies have characterized this aspect in the upstream promoter sequences of Saccharomyces cerevisiae genes. In this paper, we performed an analysis of co-occurrence of motifs in introns. Here, we first conducted a Match(tm) program to detect single motifs for transcriptional factors. Second, pairing the motifs each other, we detected some co-occurring motifs that are statistically over-represented and distributed in a non-random fashion in introns of Saccharomyces cerevisiae. These results will be helpful to understand the mechanisms of transcriptional regulation for RP genes.