(Invited) Near Infrared Optical Probes for Imaging Neuromodulators with High Spatiotemporal Resolution

摘要

Dopamine neurotransmission plays critical roles in brain function in both health and disease and aberrations in dopamine neurotransmission are implicated in several psychiatric and neurological disorders, including schizophrenia, depression, anxiety, and Parkinson's disease. Until recently, measuring the dynamics of dopamine and other neurotransmitters of this class could not be achieved at spatiotemporal resolutions necessary to understand how dopamine regulates the plasticity and function of neurons and neural circuits, and how dysfunctions in this regulation lead to disease. Probes that satisfy critical attributes in spatial and temporal resolution, and chemical selectivity are needed to facilitate investigations of brain neurochemistry.