Potentiometric Biosensor Response Calculation via Molecular Dynamics: Effect of Nanomorphology and Molecular Analyte Binding

摘要

Improved understanding of the electrostatic properties of the oxide-water interface is crucial for rational design in alarge range of technological applications such as fuel cells, water desalination and potentiometric biosensors. For example, it is currently unclear what the effect of nanomorphology such as nanopores and nanotexturing is on the pH response of potentiometric sensors such as ion-sensitive field-effect transistors (IS-FETs). Some experiments have shown increased surface area being correlated with increased pH sensitivity, and others have shown no relationship.