Wide field OCT angiography by using swept source OCT in living human eye

摘要

To investigate the application of wide field OCT angiography (OCTA) in living human eye. Normal and pathologic eyes were recruited and imaged by a 1060 nm swept source OCTA system with A-line speed of 100 kHz provided by Carl Zeiss Meditec. Inc.. Wide field OCTA images were generated in a single scan within 5 seconds based on the tracking capability installed in the system with 9 × 9 mm~2 and 12 × 12 mm~2 field of view and sampled by 500 A-lines × 500 B-frames with 2 repetitions in the same location for one 3D data. Complex optical microangiography (OMAG) algorithm was used to extract the blood flow information. The en face maximum projection provided by the device was used to generate 2-dimensional angiograms of different layers and color-code images. Wide field en face OCTA images of different macular diseases showed a great agreement with fluorescein angiography (FA). Meanwhile, OCTA provides depth-resolved information and detailed vascular images of venous occlusion and DR patients in far peripheral region, and choroidal vessels imaging in serpiginous choroidopathy patient, providing a better visualization of vascular network compared to FA.