Functional enrichment of human protein complexes in malaria parasites

摘要

This study extracted differentially expressed genes (DEG) from a RNA-Seq gene expression experiment of human red blood cells for both case and control. A protein interaction network (PIN) for the DEG at the red blood stage was extracted from protein interaction database. From the protein interaction network built, we identified 64 protein complexes using the molecular complex detection (MCODE) algorithm in Cytoscape. The functional enrichment of the identified protein complexes revealed functions related to rRNA processing, Ribosome biogenesis, RNA metabolic process, cellular process, Nucleic and metabolic process and much more which are active in the RBCs that could be open to invasion by Plasmodium falciparum.