Fabrication of the remote-controlled electrospinning machine for tissue regeneration applications

摘要

In this study, the electrospinning machine with a remote control function was developed to fabricate the polymeric nanofiber mesh for tissue engineering application. The electrospinning machine composites of the three axises control system, stage controller with high-voltage bias power supply and remote control model. The conditions of fabricated nanofiber mesh, such as dimensions, geometries and length, are defined by several parameters, including bias voltages, the injection rate of polymeric solution, stage distances between the injection needle and collection stage and moving speeds of the stage. Fabrication parameters of fiber meshes can be analyzed by using developed software and then sent from desktop computer via the wireless model to the electrospinning machine to produce required different diameters and geometry of the nanofibers. The fabricated smallest diameter of electrospun fiber reached to approximate 15 nanometers and fabricated fiber mesh had a high porosity and surface ratio that provide an ideal microenvironment for cell attachments, proliferations and differentiations as shown in the in-vitro cell culture experiment.