Synthesis of Cobalt Crosslinked Albumin Nanoparticles and In Vitro Evaluation of Macropinocytic Uptake in Gastric Carcinoma Cells

摘要

Accordingly, this study demonstrated three key outcomes: first, cancer cells efficiently internalize Co-Alb NPs while displaying high levels of macropinocytic uptake; second, Co-Alb NPs show biocompatibility and potential as a drug delivery vector through demonstrating no toxcity; third, because SNU-5 cells are not known to harbor Ras mutations, this study shows that some non-Ras mutated tumor types also rely on macropinocytosis as a mechanism of cell survival.