Construction of iPS-Derived 3D-Cardiac Myoblast Tissues Containing Blood Capillary Network by Cell Accumulation Technique

摘要

We demonstrated the construction of iPS-3D-CM tissues and introducing blood capillary by cell-accumulation technique. 25% or 50% NHCF introduced tissue showed homogeneous synchronous beating than 0% and 75% tissues. Moreover, addition of NHCF promotes blood capillary network formation. These reconstructed 3D-cardiac tissues will be useful for tissue engineering and pharmaceutical application.