Injectable Dual-Crosslinking Hydrogels to Decouple Material Retention and Mechanical Properties In Vivo

摘要

Results demonstrate the ability of dual crosslinking to be achieved on timescales for percutaneous delivery, to be retained at the target site by supramolecular assembly, and to be employed in treatment of MI. Ongoing work includes pursuit of a large animal model of heart failure, enabling longitudinal investigation of treatment efficacy and mechanism.