Collagen-alginate-hyaluronan composite hydrogels for effective culture and maintenance of chondrocytes

摘要

The Col-Alg-HA composite hydrogels were prepared to have proper physicochemical and mechanical properties of the ECM for chondrocyte culture. The chondrocytes cultured within the gel matrix were shown to proliferate actively, and to preserve the phenotypes for a long-term period over 3 weeks. The matrix is thus considered as useful 3D matrix for cartilage tissue engineering.