Nanofibrous Bicomponent Scaffolds for the Dual Delivery of NGF and GDNF: Controlled Release of Growth Factors and their Biological Effects

摘要

Bicomponent scaffolds containing designed amounts of NGF and GDNF with good post-release bioactivity could be made via DSDP-ES with E-ES. Sustained release of both GFs could be achieved. Compared with the control, mono- and bicomponent scaffolds containing GF or GFs induced much enhanced PC12 cell differentiation. Furthermore, NGF and GDNF released from bicomponent scaffolds exhibited synergetic effect on cell differentiation at certain fiber ratio(s).