Biomimetic Micropatterns Based on the Embryonic Heart for 2D Cardiac Tissue Engineering

摘要

The currently used technique of engineering cardiac monolayers was improved in terms of cell alignment by modifying the ECM pattern. We also showed that for the FN pattern that mimics the structure of FN in embryonic myocardium, tissue alignment significantly depends on the cell density. It suggests that cell-cell interactions can play an important role in tissue formation as the cues provided by ECM proteins.